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1.
usually means: The union of gametes to form a zygote; conjugation.

In this case: (A type of HANGOVER) The one of a kind, lingering,motor skill impairing,vegetating in bed all day, and hibernation causing HANGOVER you get from drinking Zygo Vodka.May also cause you to make strange complaining noises and grunts like:"whaaaa"or"ughhh"
"Holy hangover batman!..I have serious zygosis this morning..this open bar shit has to stop."

"ugh...water..please!"
by gds February 03, 2008

Words related to zygosis

hangover hang over open bar zygo zygo vodka