Top Definition
An anti-depressent used to treat anxiety/depression and the like.
"Don't forget to take your zoloft!"
by Ashley April 26, 2004
A medicine used to treat insanity...the following quote was said by Mike Tyson in an interview on ABC TV...
"That Zoloft stuff right? I take that to keep me from killin y'all."
by Tony Montana April 24, 2004
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