1). Mostly used in Italian-American communities and among the Bridge & Tunnel Crowd in the NYC/NJ area to denote a group of people.
"Ay, Billy Boy, are youze goin to that pussy palace joint downtown tonight?"
by Mr C. December 10, 2003
1 more definition
Short for, "you is".
You don't want my autograph, you'ze a liar.
by Lock and Chain July 25, 2004