Top Definition
a term used by adolescent whores prior to, after, or while doing something morally unacceptable or blatantly idiotic.
example 1:
kelly: "so I might have just given an old man a bj for some cocaine.."
lori: "what the fuck! I thought you were gonna make better choices after setting the Lawson's cat on fire.."
kelly: "fuck it, you only live once.."

example 2:
dawson: "man, can you believe it, after 2 years of being together, amber goes out and cheats on me! then, to make it worse, she tries to defend herself by saying 'you only live once!'.. fuck her."
ken: "so not cool. what a fucking stupid whore."
by sick of dumb sluts October 10, 2011
1 more definition
I agree with the above definition. It is also a song by The Strokes.
You only live once is one of the strokes best songs.

by Quitelate September 07, 2006

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