look up any word, like hipster:
 
1.
when you're unable to manipulate something put into your possessions or unable to control someone or something into a stable range of management.

other interpretations:
you can't handle this
you can't handle it
boy: can i talk to you for a second?
girl: no.
boy: can i just...
girl: no.
boy: well, just...
girl: no.
boy: you can't handle me, anyway.
by youcan'thandleme November 20, 2007