look up any word, like spook:
 
1.
hey, how are you doing
john "yo sup"
sarah " not much u"
by goldendeath1134 August 31, 2005
 
2.
Yosup is the word all the cool kids use as a greeting.
Its a shorter way of saying "Yo, what's up?"

Person 1: YOSUP!
Person 2: Nothing much.
by Justin June 16, 2006