Variant of "Yeshua" or "Yushke" used in Hebrew- or Yiddish-speaking and other Jewish communities. Sometimes derogatory, "Yeshu" is usually just used by Non-Messianic Jews who just don't know better.
The derogatory use of "Yeshu" is an acronym to refer specifically to the Messianic Jewish
) and historical figure Yeshua
in terms of "Yemach shemo
uv'zichrono"-- literally, "May his name and memory be wiped out."