Top Definition
X (Ecstasy) O (oxycodone) XO is a mix of those two, familiar with RnB artist The Weeknd as he uses it as his brand as well as ho's drug of choice
I was sippin on xo last night.
- Hugs and kisses?

No, xo the drug, I felt so warm and relaxed.
by blazeee March 10, 2014

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