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the literal meaning is what the fuck is up. it can be used as a question, greeting, or interjection.
Ana:(to friend) Hey look its that hottie kyle
Kyle:(to me) Its that bitch ana again
Ana: hey kyle, how have you been?!
Kyle: WTFIU!
WTFIU by Chode Trickery May 5, 2011

WTFUppercut 

A "what the fuck" moment in which you just got pwned.
Person1 *Betrays Person2 with a melee from behind*

Person2: WTFUppercut!
WTFUppercut by J_MASTER March 19, 2010

Wtfiuknwdysdwtfdstfuk 

What the fuck is ip kyle no what did you say dude what the fuck dude step the fuck up kyle
Others : Wtf

Me : Wtfiuknwdysdwtfdstfuk

wtfiuknwyswtfdstfuk 

what the FUCK is up, kyle? no what’d you say? what the FUCK dude. step the FUCK up, kyle.
person 1: fuckin’ dumbass.

person 2: wtfiuknwyswtfdstfuk
wtfiuknwyswtfdstfuk by meinux June 12, 2018
Short for "Wake The Fuck Up, Pal". A supremely condescending and passive-aggressive way of telling a "friend" who's a government employee, stoner, unemployed, etc. that you think they are lazy and should get their ass in gear.
Simple text message: WTFUP.
WTFUP by FrostyCan June 20, 2015
Short for, "What the fuck is your problem".
"I hate you and I hope you die!!!!"
"Dude. WTFIYP today?"
WTFIYP by electronicbattleground November 8, 2004