The feeling of mild depression and high anxiety when one has binged on large amounts of psychoactive substances, just as those substances, which had caused a high, where off. Usually the testy, easily annoyed, "bug-eyed" feeling brought about as stimulants such as cocaine or amphetamines leave one's system. One usually, to counteract the unpleasant wig out feeling, drinks large amounts of alcohol, smokes weed, or consumes larges amounts of anti-anxiety benzo pills like xanax.
Oh wow, I'm about to wig out. I need some xanax and weed, or else I'll go nuts. I took too much adderall. Wow.