(Note: This may just be a baltimore thing.)
Can also be used in different forms.
From a different perspective:
"Damn yo, he just whored you UP!"
Sara: Hey, don't be so hard on her, she went to some swingers party a few months ago and got herself "Whored Up" by some guy, she is due in about 4 months.
Jenny: That will teach her. And she still looks like a whale, even if she is "Whored Up".