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2.
Originally stemmed from military jargon; means to depart from or leave an area or place, particularly via airplane.
I'm wheels up tomorrow.
by MrOklahoma April 03, 2011
 
1.
the time or point when a plan or operation is executed. it comes from the military to describe when a plane lifts off to start a deployment, at that point an operation is considered hot (officially started).
We have to be packed and ready to go by 7:30 so we can be wheels up by 8.
by goopup January 29, 2006
 
3.
The phrase that fictional character Aaron Hotchner declares once choosing a case to investigate in the hit CBS show 'Criminal Minds'.

Once stating 'Wheels Up' the team go off to kick un-sub ass! Also, they always win.
'Aaron Hotchner take us back... WHEELS UP!'
by thecriminalprofiler November 06, 2011
 
4.
After a wealthy, major sports figure is put out of contention he/she exits on their private plane
Tiger missed the cut at the U.S. Open and he was wheels up Friday afternoon
by ses-old July 22, 2006