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1.
the time or point when a plan or operation is executed. it comes from the military to describe when a plane lifts off to start a deployment, at that point an operation is considered hot (officially started).
We have to be packed and ready to go by 7:30 so we can be wheels up by 8.
by goopup January 29, 2006
 
2.
Originally stemmed from military jargon; means to depart from or leave an area or place, particularly via airplane.
I'm wheels up tomorrow.
by MrOklahoma April 03, 2011
 
3.
The phrase that fictional character Aaron Hotchner declares once choosing a case to investigate in the hit CBS show 'Criminal Minds'.

Once stating 'Wheels Up' the team go off to kick un-sub ass! Also, they always win.
'Aaron Hotchner take us back... WHEELS UP!'
by thecriminalprofiler November 06, 2011
 
4.
After a wealthy, major sports figure is put out of contention he/she exits on their private plane
Tiger missed the cut at the U.S. Open and he was wheels up Friday afternoon
by ses-old July 22, 2006