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4.
An area of knowledge, specific interest, and familiarity...
Dude One: Will you look at the set of tits on that babe??

Dude Two: Damn...That's right in my wheelhouse!
by Roundhead December 04, 2009
 
8.
Location or area on the front of the human body between the neck and the abdomen.
The quarterback passed the ball to the receiver right in his wheelhouse.
by B Stanton September 19, 2005
 
9.
someone's personal space. can be used when someone is in your face, or in your business.
dude, get back, your all up in my wheelhouse.
by fenderbender298 July 10, 2008