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15.
A question about what another has his attention on. What is he thinking about or busy with? "Up" in this usage is referring to a slag from around the 1930s meaning: occupied with or busy with.
When I saw him he was angry so I asked "what's up?". But he would not tell me what he was angry about.
by Scottmana September 15, 2007
262 281
 
16.
The things that are up.
Hard dicks and helicopters.
by The Man June 16, 2004
57 90
 
17.
Used to mean "she/he/you is/are very attractive and I would very much enjoy making love to you." It is derived from "A Night at the Roxbury"
Steve: What's up? What's up? What's up? What's up? What's up?
Doug: Steve, slow down.
Steve: I can't help it man, it's hottie overload.
Doug: Just pace yourself.
Steve: Ok... What's up?... 2, 3, 4. What's up?... 2, 3, 4...
by Tonberry2000 April 21, 2009
139 233
 
18.
comunication between friends
what's up Fred?
by Erica Abreu July 31, 2003
109 212
 
19.
An interrogative expression used to request a clarification or repetition of something previously said. Used in place of "what?"
Person 1: "You're not paying attention to me."

Person 2: "What's up?"
by Ian May 02, 2004
118 222
 
20.
A term usually used by young African-Americans(mostly males), used in order to figure out if the person they are speaking with wants to "step" to them.
"You tryna mack on my girl dawg? So what's up?!"
by candice D May 11, 2005
79 306