1. A query
as to one's preference, specifically in regards to consummable goods
2. a query as to one's preference in alcoholic beverage
3. a question of one's preference in women
1. Alfred: What's your poison?
Rudyard: Give me a slice of pepperoni, beyotch!
2. Alfred: What's your poison?
Rudyard: Give me some mother fuckin' crack!
3. Alfred: What's your posion?
Rudyard: I likes me the big-titty bitches yo!
What do you want to drink.
Bartender asks a patron, "What's your Poison?"
usually said by sleazy guys in bars as a way of asking to buy you a drink
"hey...What's Your Poison"
"baileys now feck off"
What are you drinking? Usually in terms of alcohol
"Whats ya poison?"