look up any word, like fleek:
 
2.
Implying that someone else is crazy when they're merely pointing out your foolishness.
Willis: Don't you think you'd better put the lid on that blender full of gunk before you plug it in?

Lil' Fool: What you talkin bout willis? (as he plugs in the blender)
by Liv Pooleside January 28, 2006
 
1.
Famous quote from 80's tv sitcom "Different Strokes"

Used in normal conversation when speak doesn't understand.
"what you talkin bout willis?" -- translates to: "I did not understand"
by Butifuco November 17, 2003