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1.
What is the matter?; Do we have a problem here?; Made famous by Martin Lawrence
Jermaine already paid you you're money, so what the problem is?
by Stainz June 25, 2004
 
2.
An absolutely hilarious interrogative question directed to any person when asking "What is the problem?"
I don't go to schoo anymo' what the problem is?!!?!??
by Not Zane September 16, 2004
 
3.
what happened how can i help you out of your ethical quagmire
yo why u walkin, what the problem is?
by lil homie 1011 January 29, 2005