Top Definition
the weekend begins and you party all weekend, getting smashed every night, when you finally go to work on monday morning you sit down only to find you can't remember what you were doing on Friday before the weekend. This is particularly bad when its a long weekend, like easter
After a weekend of partying Rob sat down at the Monday morning meeting to discuss plans for the week and last weeks completed work, when it was his turn to address his colleagues, he said, "sorry, i have weekendnesia, I don't know what I am doing this week or what I did last week"

I hit the pubs and clubs so hard this weekend I have weekendnesia.
by siffbachelor April 21, 2009

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