Also, to have a large amount of poisonous chemicals in your sytem.
You can not be WASTED if you only have marijuana in your system, because marijuana does not consist of the lethal toxins that other drugs contain.
1- Drunk or otherwise intoxicated off your ass
2- The act of obliterating something or someone in a computer/video game, not always online.
2- Holy shit man I just wasted that dude with a rocket.