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1.
a natural change visible in nature or people
by BLED FOR DAYS December 03, 2002
 
2.
Quite literally change, or chaotic nature. Vicissitude would be used to describe the emotional state of mental patients or the chemical properties of nitro and glycerin.
Vicissitude is a word that is used mainly to belittle others in that very few people know it's meaning.
by Nathan July 17, 2004