Top definition
to instantly disappear, make as though it never was.
Izzo- H to the Izzo V to the Izza. he who does not feel is not real to me, and therefore does not exist... so poof vamoose son of a bich (South park movie reference)
by blink fanatic January 12, 2005
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2
to leave or depart hastily (from Spanish, Vamos meaning let us depart)
I've gotta vamoose or I'll be late.
by The Return of Light Joker June 30, 2009
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3
Scram, take off, go away, gtfo.

Comes from the Spanish vamos - the word transitioned into American English as a result of contact with the Spanish colonies in Mexico.
Trust me holmes, you don't want to start shit with me. Vamos, esse.
by Tronno July 31, 2005
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4
Jay-z's Song "poof, vamoose son of a bi***"
by Ariana March 29, 2004
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5
Move now, get out of here, move your bottom please.
Gardener to flock of distructive birds: vamoose you darn birds!!
by crayola March 30, 2004
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6
Make an expedited departure. scram
You - you're bugging me. Vamoose.
by DHG March 30, 2004
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7
You'd better vamoose before my girlfriend catches us.
by LB March 31, 2004
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