Top Definition
An unexplainable and inconsistent state of mind that comes from having a vagina. ALWAYS eventually results in senseless or irrational behavior by a woman.

The most prominent reason a man can never truly have a female best friend.
"I thought she was the first girl I could actually understand, she seemed cool."
"You underestimated the effects of vaginophrenia, my friend."
by Cullen/ RW August 03, 2008

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