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1.
Shaq's epic reply to Oprah's all caps message on twitter, which has all the signs of being an incipient meme. You will probably see it used whenever someone writes in all caps.

Ironically, it's likely that Oprah was holding down shift instead of having caps lock on because the 'st' in '21st' is lower-case.
Oprah: HI TWITTERS . THANK YOU FOR A WARM WELCOME. FEELING REALLY 21st CENTURY .

Shaq: @oprah ur caps r on, btw

by Glueboy April 20, 2009