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upthumbs 

A much cooler way to say "thumbs up"
You can chug a gallon of milk? Upthumbs!
upthumbs by Dr. Seuss, PhD July 20, 2011

upthebuttgirl 

n. Word referring to a girl who lets her boyfriend have buttsex with her. She is henceforth known as the "upthebuttgirl" by him and all his friends.
I do NOT want to be the upthebuttgirl.
upthebuttgirl by danielle July 27, 2005
Uptheduff

1. The slang term for being pregnant

2. A drinking toast with Duff beer in the Simpsons
Example: She’s uptheduff again

Example: I’ll uptheduff to payday, to dooh
uptheduff by ITman October 7, 2007
An Aura Beast something that ruins everything with thier suck
That guy is such an upther.
upther by hiawa March 28, 2005

upthebuttomy 

The vernacular for the outpatient surgery to check one's colon for pollops. Often referred to as a colonoscopy by professionals. The term can also be used to describe the procedure required to remove office brown nosers.
Geez, now that I've turned 50, I've got to go get an upthebuttomy.

Eric is such a brown noser that I'm going to have to get an upthebuttomy to remove him from my ass.

upthebuttology

the study of all things that go up the human butt
I study upthebuttology in my every day life because it is my career as an upthebutologist.
upthebuttology by mcdicksucker November 1, 2010