having so much down syndrome that you dont even know what is going on. you must have a lot of downs to be able to get upsyndrome. this is a very rare but life threating disease. but by having upsyndrome you are automatically a playa.
guy 1: is that an upsyndrome over there!?
guy 2: duh. he is so dumb. but he is a boss at the same time.
guy 1: word.
1. The state of one's PENIS being in a perpetual state of happiness.
"Ever since meeting Caroline, I think Tom has come down with a bout of up-syndrome."
"...It really sucks having your upsyndrome flair up at a gay bar..."
We always thought Susie was weird, then the truth reared its ugly little head -- out of her pants when she was diagnosed with up-syndrome!"
5:00 News Headline:
"Rare condition found in man with up-syndrome -- are two penises better than one?"