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4.
A greeting, usually reserved for close friends and often preceded by "what." Can be expressed as a question or a declarative statement.
What upper?
Nothing, man. Upper.
by cyt O. February 26, 2012
15 11
 
1.
street classification of any prescription or non prescription substance that is a CNS stimulant, common physical side effects of "uppers" are:

increased heart rate
anxiety
tingling
feeling "buzzed"
Amphetamines (speed)
Methamphetamines (meth)
Ecstasy
Ephedrine and Psudo-Ephedrine
Cocaine and Crack
by J January 10, 2004
278 93
 
2.
Stimulating pill or drug, e.g. speed or meth; see whites
We kept popping uppers as we drove across Texas that night
by cornholio October 16, 2003
115 17
 
3.
The term uppers is a street name for amphetamine-based psychostimulant drugs that produce increased wakefulness and focus, in association with decreased fatigue and appetite. Also referred to as speed, uppers are widely used recreationally as a performance enhancer for athletes and college students, and abused as a weight-loss supplement. In the United States, uppers are also consumed as a prescription to treat ADD (Attention Deficit Disorder) and ADHD (Attention Deficit Hyperactivity Disorder). Examples of these include the brand-named medications Adderall, Dexedrine, Dextrostat, Desoxyn, ProCentra, and Vyvanse, as well as Benzedrine in the past (due to high recreation use as early as the 1940's).

Other narcotic such as MDMA (ecstasy), methamphetamine (meth), and cocaine can also be colloquially referred to as uppers.
"Hey, could I buy uppers from you? I have a huge paper to write tonight."
by ILoveLamp12! April 27, 2012
24 7
 
5.
the opposite of downer. a person who can lighten the mood and make you feel better without even trying. a person who you feel came into your life just to make you feel happier about everything.
'who is that guy'

'his name is rhys, he such an upper, he makes me smile all the time'
by a bee h August 13, 2012
6 6
 
6.
a drug that is a stimulant and makes you.. hyper. Some are crack and/or ectacsy <s/p>
I need some uppers to get through class today
by Insane February 07, 2004
59 78