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1.
another way of saying "up in here." Only it's a way better way of saying it because peoples know you mean bizness cuz of the expletive.
Damn dude, I gots the munchies. We need some brownies up in this bitch.

by throwsomecheeseonit November 27, 2007
391 31
 
2.
The Swahili term used on the Orange River, the border of South Africa and other neighboring countries, referring to intense shit going down.

Alternative phrases include "up in this world" and "YO MAN" however they all hold the same meaning, up in this bitch!
"Damn nigger! That shit be crazy up in this bitch"

This can refer to any circumstance when you are overly excited for a reason, or just tripping balls. Traditional geographical locations for use of this term are majorly used while rowing down the Orange River.
by Rifle/Rafe October 14, 2011
12 42