occurs when one or both of your balls is in a state of uncomfortable-ness. common precursors to said condition include but are not limited to, excessive exercise, extreme heat in the genital region due to tight pants in warm weather, wedgies, other forms of underwear bunching, nervousness, extreme cold, fear, and/or being a witness to a sex scene between Rosie O'Donnell and Courtney Love. This condition has no treatment, only time will heal.
Joe: "hey man, whats wrong?"
Matt: "i spent the night at the girls house from the bar last night."
Joe: "please don't tell me you have blue balls!"
Matt: "even worse. when i got there she put on two girls one cup and I've had uncomfterballs ever since!"