Twubs is a simple combination of the words "twins" and "chubby", meaning that "twubs" means chubby twins. The word is most commonly used when bro's (or ho's) are discussing their latest awesome sexual escapades.
A: "Yo bro I totally nailed these two hot twubs yesterday! And guess what! They wanna hang out again on Saturday!
B: No way! Dudeski, you know I love twubs! Pick me up on the way there and we can double team that shit! Just like the old days! Slappin' fat titties side-by-side!
A:Damn straight brofo! And maybe after we're done with the chubby twins, we can touch dicks!"
"...went to the mall today... saw some twubs. Scariest thing ever."
1. a cracked out squirrel
2. the inside of your elbow, opposite of your wenis
1. Stop acting like a twub.
2. My twub is ticklish!
3. I hurt my twub this morning chasing a twub.