Top Definition
noun informal
1. a young person, esp. a teenage girl, who is an ardent admirer of rock musicians and may follow them on twitter.
2. an ardent fan of a celebrity or of a particular activity
3. a dumbass person who follows celebs on twitter and thinks their really friends with them and writes on their walls and expects responses..

And yes Errisson did come up with this first.
The majority of people on twitter are twoupies.
by Errisson June 28, 2009
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