A latino street gang named after 26th ST in Chicago's Little Village community. The gang was originally a neighboorhood baseball team called the Two Sixers but formed as a street gang in the 1960's. One of Two six's biggest rivals is the Latin Kings.
Hey ese, look at that vato walkin down 26th, he wearin' black & tan, he must be a Two Six.
by Little Village Vendor July 12, 2009
A Canadian term for a 26-ounce bottle of alcohol. The modern bottle is actually 750 mL (25.36 oz), but it is still commonly called a two-six nonetheless. (See also: two-four.)
I finished off a two-six of rum in one evening, and did not feel good the next morning.
by Some Guy (2q38f7bdo73h2sdlh) October 12, 2005