a way of saying "peace", often used as a sign off or a symbol of one's departure. the name is derived from the two fingers that go up when making a peace sign with a hand.
Rick: "Remember that we gotta' pick up Susan tomorrow."
Bill: "Alright, man, i'll remember. I'm calling it a night. Two up."
Simoultaneous sex with a womans rear and front entry
Ooooh that must hurt!