look up any word, like fleek:
 
2.
The act of putting your fingers into your lovers anus, grabbing hold, then you twist your hands and pull your hand out causing them to shout in pain
Steve gave Betty such a good twist and shout that her asshole began to bleed
by Tom December 09, 2004
 
1.
A combination of utter beauty and the burning pain of a thousand suns, wrapped into a single fanfiction. Readers have, on many occasions, wished death upon themselves for reading it, death upon others for writing it, and commonly use the phrase "Twist and rip my fucking heart out." Additionally, due to the previously mentioned pain of the narrative, readers, after finishing this emotional hell, have severe emotional reactions to seemingly harmless phrases. For example, "I can dig Elvis," "See you then," and even the three little words, "I love you," bring on a wave of uncontrollable pain. Those who have read it share common masochism, inability to listen to the music of Elvis Presley, and fear of beaches.
Person 1: "Wow, I'm kind of concerned. I thought it would be fun to take a family trip to the beach, but she just had this breakdown once she saw the water."""

Person 2: "I know. I talked to her a little bit ago, but I could hardly understand her. Something about Twist and Shout?"
by ICanDigElvis July 30, 2014
 
3.
Throwing up and diarrhea at the same time.
Man I was so sick last night throwing up and diarrhea I didn't know which end was gonna let go next. My friend you had a major case of twist and shout!!!
by L Ray August 29, 2009
 
4.
a method of masturbation brought to light in an episode of the HBO series Real Sex whereby a man uses a twisting motion of his hand on his shaft and then lets out a vocal shout
"Is Jamie going to come out with us on a fun pass?"

"No, he'll probably just sit at home all night doing the Twist and Shout."
by Squall1 February 03, 2010