Top Definition
The underlying condition that is the cause of tweet twitches. One contracts twiphilus through the creation of their twitter account. The condition may lie dormant for long periods of time and then erupt in a series of tweet twitches. The tweet twitches are highly likely to aggravate the twiphilus present in other twitter users who are following the twiphilus victim. There is neither a cure nor a treatment.
Sarah has a terrible case of twiphilus. I just checked my phone and I have 20 unread tweets from her. The worst part is I later realized that I responded to almost all of them without even realizing it.
by AmericanSwagSociety April 09, 2011

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