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15.
A confident, young (early twenties or younger) attractive male, often preyed upon by 'cougars'.

Twinkies have almost no defence against the experience and sexual wiles of a cougar and this can result in them feeling like a piece of meat at the end of an encounter when the cougar disposes of them.
After being trained by a cougar, the sexual technique of a twinkie will be improved significantly.
Cougar to fellow cougar; "Check out those twinkies over there, which one do you want?"
by cougar987654 October 02, 2013
 
16.
The original usage of twinkie occured circa between fall/spring 1979 or 1980 when I, a female guitarist and actress, was in a punk rock band rehearsing in a "music building" in Manhattan on 38th street. I would pick up a twinkie before rehearsals and eat them on breaks and the singer in my band started calling me a twinkie. That summer I went to work at a summer stock theater on LI where I started using the word around anyone being extra silly or acting out (i.e. doing a lot of twirling or drag, or being fabulous in some way, etc.)...the guys, most of whom were gay dancers, caught onto it. Within a couple of years the word was being regularly used in the gay community for any young, fun partying gay boy. That is the true origin of the usage of twinkie on the gay scene and how it came about as it had never been used in any context prior to that except in reference to the yellow packaged creme filled cake.
You're such a twinkie!
by twinkietrue June 13, 2011
 
17.
a 20 sack of any drugs especially weed or coke
i get in the streets by grinding on the block sellin twinkies allday
by zany zane January 31, 2008
 
18.
One who thinks they are really awesome, yet are not; based on the fact that, while Twinkies have a reputation to be extremely good, they are terrible.
"That douchebag is such a twinkie."
by P Norment January 12, 2012
 
19.
A term describing a very sweet, cute girl who is mentally a lightweight.
"What's wrong with that girl?"
"She was a twinkie - nice and sweet but not all there"
by knownslacker July 10, 2008
 
20.
any statement that can be taken out of context in a sexual way. usually yelled out.
a friend when describing her favorite type of purse, said very loudly, "i like the big, black ones!" (so in response we say either just "twinkie!" or "that's a twinkie!"); even just simple statements like, "i'm easy," i'm flexible," or "i'm open," could be twinkies;" another example, my friend ben, arriving late just behind another group of tardy girls said: "i'm glad you came right before i did," and the girls responded "twinkie! that's the way it should be."
by billie michelle allen June 17, 2008
 
21.
Chicago slang word meaning $20 or $20 worth of dope.
Yo folkks you got a twinkie of dro you could slang me???
by D FolKKz April 24, 2008