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1.
Blaming your own fucked up actions on unrelated external factors. Basically, a complete bullshit excuse for doing something really fucked up. Taken from a famous court case where an accused murderer blamed his actions on a sugar high he got from eating too many Twinkies.
What do you mean? You only fucked that sheep because the moonlight made you horny? Fuck! That's a twinkie defense if I ever heard one, sheepfucker!
by Paul Thundergod June 24, 2003
98 35
 
2.
A defense tactic which seeks to excuse someone's behavior by evading responsibility. In the actual case, the defense effectively blamed the actions of the defendant on too much sugar derived from eating Twinkies.
I am not buying into your Twinkie Defense.
by CDA gf November 09, 2009
11 4
 
3.
O.K., this is the REAL Proud Conservative. Not his groupie.

The Story of the twinkie defense is thus:
In 1978, Dan White, a former San Francisco city supervisor who had recently resigned his position, entered San Francisco City Hall through a basement window, went upstairs, and shot and killed Mayor George Moscone and Supervisor Harvey Milk.

Psychiatrist Martin Blinder testified in court that White had been depressed, which led to eating junk food: Twinkies and Coca-Cola. This further deepened White's depression, since he was an ex-athlete and knew that the food was not good for him. This was evidence of his depression that prompted his murder spree. This celebrated diagnosis became known as the "Twinkie defense."
(Taken from www.ohnonews.com)
by Proud Conservative August 27, 2003
108 125
 
4.
The stance or posture taken by a fat person when you try and take food from their plate.
"I tried to bum a fry from JoJo's plate and that fool struck a "twinkie defense"."
by D. Ferrel September 24, 2003
10 66