the act of being really fucked up. It is used to describe being extremely drunk, high or tripping. It is not used, for example, if you just had a few beers.
EX1:(Past)- Dude, I was straight twigglin last night. I can barely even remember what we did.
EX2:(Present)-Bro, im twigglin so hard right now.
EX3:(Future)-Man i cant wait to be twigglin later tonight.