Top Definition
flipping the fuck out on cocaine, meth, caffine, nicotine, ect.
"Dude did you see Sarah last night she was all twigged out doing cartwheels and shit!"
by hannelore May 11, 2007
A term to describe a hella skinny person.
Dude, that chick is hella twigged out! That's nasty!

Lyndsay Lohan is mad twigged out!
by FemmeFatale June 21, 2005
A term referring to a state of mind. Meaning out of it, feeling separated from society and your normal life. Possibly a loss of your self identity. Usually used in context with LSD.
After that crazy acid trip, Sid was really twigged out.
by hoarselady April 05, 2015
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