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1.
flipping the fuck out on cocaine, meth, caffine, nicotine, ect.
"Dude did you see Sarah last night she was all twigged out doing cartwheels and shit!"
by hannelore May 11, 2007
10 2

Words related to twigged out:

hella caffine cigarettes cocaine mad meth nicotine
 
2.
A term to describe a hella skinny person.
Dude, that chick is hella twigged out! That's nasty!

Lyndsay Lohan is mad twigged out!
by FemmeFatale June 21, 2005
5 4