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To be in a combined mental state of tired and wired.
I see my colleague in the elevator on the way to the meeting room. I ask him how he is doing. He says, "I have been up all night to prepare this presentation for the board. I've been working on it non-stop for three days. I've been drinking coffees like a bandit to stay awake. I'm so toasted. I'm so wired, too. Man. Hell, I''m twired.
Twired by Royal Wulff November 27, 2012
Related Words
twired twiced Twixed Twiberal twinbed tribed Twibe twibel Twibernating twined
Making a person repeat the exact phrase over again unintentionally.
Nick - "I just got my ass kicked in brawl."

Noah - "What?"

Nick - "I just got my ass kicked in brawl."

Noah - "Twiced."

Nick - ...
Twiced by PolarBearNinja August 13, 2012
Noun - A LIBEL lawsuit based on a Twitter Account public posting. Was frequently used with Courtney Love being sued for a "tweet" that was considered disparaging. May be seen as the first step of Twitter, and other Social Media platforms, as a legitimate news source with First Amendment implications/protections.
Courtney Love being sued for a 2010 Twitter post regarding her attorney. "Twibel" was coined by concatenating Twitter + Libel. The term was used in reports by various sources including ABC News, the Huffington Post, Media Bistro, and the American Bar Association Journal. A jury found in favor of Ms. Love in January 2014 (i.e., cleared).
twibel by eCzarina January 30, 2014
Being so tired that your body tries to make up for it in a ridiculous level of stupidity. The result is an a very hyper (wired) person that you need to convince to sleep.
Twas the night before the exam, and the student was twired as all hell.
Twired by JJ Rylee October 24, 2016
A small group of Twitter Friends who mostly Tweet @ each other.
Since He has the most followers, @insertname is our Twibe Leader.
Twibe by BrahmShell April 6, 2009
Running over something that's all ready been hit and dead in the road. Also, haxing sex with someone two times in one occasion.
"Oh sick, you twiced it!"

or

"Yeah, I twiced her."
Twiced by Lonelily January 18, 2008