According to the late Kurt Vonnegut, a twerp is someone who shoves false teeth up his rear end and bites the buttons off of the back seats of taxi cabs.
That Luddite over there is a real twerp.
A younger kid that is an annoying pest.
That twerp just stole my sandwich!
Someone put a lid on that little twerp.
Ash Ketchum and any of his friends, according to Jessie, James, and Meowth.
Jessie: Oh no, it's the twerps! Time to get that Pikachu...
annoying "twerp" with a high pitch squel in your ear when you wake up in the morning feeling digusted to hear a pre-pubed boy singin and prancin like a balet and fat viking singin chick type combined.
A Short annoying person. Usually a younger person.
Dude, your little sister is a twerp!
AKA Mitra Yosri
A kid who farts in the bathtub and eats the bubbles.
Fargas: Was that your kid in there with his face in the bathwater?
Mick: Yeah, he's eating his farts.
Fargas: That little bastard is a real twerp, just like his old man.
Mick: Fuck you!!!