The second funniest number in existance. Can be used to answer almost any question. The number really just has a decent ring about it
joe:"man how much longer do we have to wait?"
tim: "about twenty-two minutes"
joe:"lol twenty-two"
by Joncyclark November 19, 2006
When a man is kicked in the testicles, resulting in blackouts, inability to walk, and a jelhon.
"That guy got twenty-twoed."
by Bubba Johnson July 22, 2006
A low caliber rifle, very little destructive power.
Brian shot me in the head with his .22 and I walked away
by Luciano December 15, 2003

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