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short for Twitter Family. These are our friends that you follow on twitter and are constantly updating. They update so frequently that you know what they are doing every minute of the day. After following them for awhile, you know them so well that you now consider them your family!
Hey, let's go watch toy story 3 with the tweetfam!

She's not a part of our tweetfam because she doesn't tweet enough and doesn't tweet us.
by Jonnyvlogs June 26, 2010