The biggest fag within a group of friends, generally shaky and uncomfortable.
God, josh, what a tweek.
by Jack Daniel Smirnoff March 24, 2011

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A character from the T.V show "South Park". He has very messy blonde hair and supposedly sufferes from A.D.D but his twitching and nervous personality is due to the large amounts of caffeine he consumes. In Series 6, Tweek became the main characters replacement for Kenny, alongside Butters, after he "permeanantly" died at the end of the previous series.
"Tweek's the worst character ever."
"Yeah. Worse than Towelie."
by Issy Aidsfunop January 15, 2006

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Someone who gets around
Alvin is a tweek, all he does is tweek with all the boys in the class
by BigPappa12345 September 12, 2011

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Soft and offensive. Just like you.

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Something or someone that is stupid, dumb, or crazy.
"Stop being such a tweek !"

Person#1: I failed the history test.
Person#2: That was so easy, you tweek !
by kimbop October 03, 2009

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The Urban Dictionary T-Shirt

Soft and offensive. Just like you.

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The Urban Dictionary T-Shirt

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something that looks strange or is very cool
dude that shit is tweek!
by steakman1 February 10, 2007

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The Urban Dictionary T-Shirt

Soft and offensive. Just like you.

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The Urban Dictionary T-Shirt

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To pinch or flick...

"I tweeked her nipple and she tweeked my clit with her tongue."
by Junebug December 14, 2005

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The Urban Dictionary T-Shirt

Soft and offensive. Just like you.

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The Urban Dictionary T-Shirt

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to enhance
"Dude, check out my tweeked up motorcycle..."
by kevsgrl2004 June 09, 2003

The Urban Dictionary Mug

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The Urban Dictionary Mug

Your favorite word on a white mug.

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The Urban Dictionary Mug

One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.

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The Urban Dictionary T-Shirt

Soft and offensive. Just like you.

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The Urban Dictionary T-Shirt

Smooth, soft, slim fit American Apparel shirt. Custom printed. 100% fine jersey cotton, except for heather grey (90% cotton).

Buy the t-shirt