The biggest fag within a group of friends, generally shaky and uncomfortable.
God, josh, what a tweek.
by Jack Daniel Smirnoff March 24, 2011
29 more definitions
Verb. A side effect of extreme over indulgence in crystal meth or crack cocaine. Tweekers typically perform OCD-like activities centered around finding small quantities of drugs that were inadvertently "misplaced". Tweekers may be seen on all fours, searching in gutters, obsessively looking under various objects and so on. In certain circumstances, extreme tweeking resembles autism or catatonia.
by Slagathor April 23, 2004
losing oneself in a senseless task while under the influence of speed.
She would tweek all night cleaning the house and pulling apart electronic devices.
by chillcat May 29, 2003
A character from the TV show "South Park". Tweek is the ADD kid, who is constantly twitching. He often rants and raves about things that only he sees, and is addicted to coffee. Tweek is in love with Craig, and they sex each other.
Wow. Tweek sure has sex with Craig a lot. It's hot.
by The Lord Of Spam February 16, 2006
the nervous ticks or twitching one experiances as they come down from a crystal methamphetamine binge.
pulling hairs out of their face; picking at their face; picking their nose...
by a former tweeker November 28, 2003
Similar to a Gleek, the Tweek is the Twilight version. Geek + Twilight = Tweek
OMG I am sooo excited to go and see the new Twilight movie, I'm such a Tweek!!
by Sazilicious July 02, 2010