Someone who Twitters obsessively on the social networking site "Twitter." Twitter + Geek = Tweek. Often appearing to be normal people on the surface, they will quickly reveal their inner geek whenever anyone mentions Twitter in a conversation, at which point they will tell everyone within earshot about all the hilarious and uninteresting things their friends and acquaintances have recently tweeted about.

See also "Twatter", someone who tries to accumulate a large following on Twitter in order to hide the fact that they are actually a giant twat.
Rational human: "I can't believe CNN is reporting on what politicians are tweeting from the halls of the Senate...or that politicians are tweeting in the halls of the senate, for that matter."

Tweek: "OMG I LOOOOOVE TWITTER!!! My friend Jessica just tweeted about how the guy next to her in line at the DMV just farted and she said it smells like a mix of hot garbage and a yeast infection!!! How funny is that?!"

Rational Human: "I hate your face."
by thepoolboy October 05, 2009

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Top Definition
Verb. A side effect of extreme over indulgence in crystal meth or crack cocaine. Tweekers typically perform OCD-like activities centered around finding small quantities of drugs that were inadvertently "misplaced". Tweekers may be seen on all fours, searching in gutters, obsessively looking under various objects and so on. In certain circumstances, extreme tweeking resembles autism or catatonia.
Yo! Check out that tweeking crack ho!
by Slagathor April 23, 2004

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A character from the TV show "South Park". Tweek is the ADD kid, who is constantly twitching. He often rants and raves about things that only he sees, and is addicted to coffee. Tweek is in love with Craig, and they sex each other.
Wow. Tweek sure has sex with Craig a lot. It's hot.
by The Lord Of Spam February 16, 2006

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losing oneself in a senseless task while under the influence of speed.
She would tweek all night cleaning the house and pulling apart electronic devices.
by chillcat May 29, 2003

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the nervous ticks or twitching one experiances as they come down from a crystal methamphetamine binge.
pulling hairs out of their face; picking at their face; picking their nose...
by a former tweeker November 28, 2003

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Upper, crystal meth
can I have a bump of tweek?
by Cosmo Wash.DC December 26, 2002

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to adjust or fix
Let me just tweek your computer.
by Tracy Lukeman October 20, 2003

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A person that appears to be on any controlled drug or any street drug. altering their mind in an overly dramatic way.
He/she comes to work everyday high, appears to be on some mind altering drug. Acting over dramatic about the smallest things. this person is tweeking
by ColdOneOnly January 22, 2017

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