1. Someone that is on meth/speed
2. Someone could be called one for talking alot, pacing or moving alot or doing a task with an unusual amount of persistence, most of the time at unusual times late at night/early morning
3. You wont catch this person sleeping or eating. all though the food still looks good..
"Hey man uve been cleaning them rims for like six hours now and your on the second wheel, You tweakin?" (this is at 6 in the morning on a saturday after staying up all night, He sure was.)
by Cowshit101 June 02, 2009
1.To be high on stimulants like Meth or coke.
2.To work obsessively or compulsively on something.
3.To adjust something.
4.To be way wrong about something
1.He did 4 fat ass lines, hes tweakin hard
2.I was tweakin on my room for like 4 hours
3.I was just Tweakin the carb on my truck
4.you think the Boston Celtics are the best team ever..man your tweakin.
by Steve_Juggernaut April 28, 2006
Outside of your normal boundaries
Boy 1: "Which came first the chicken or the egg?"
Boy 2: "Boi, what the.."
Boy 1: "My fault I'm tweakin"
by Giddy April 24, 2005
(v) To be high on amphetamine.
"We be tweakin, like every single weekend, we be tweekin."

"Last night I danced for 10 hours, I was tweakin hard."
by saeed October 20, 2003
1) to be high on stimulant supplements(vitamins) or drugs.

2) to be hyperactive.
1) sugar, caffeine, monster drinks, sugar, earl gray tea, amphetamine, methamphetamine are examples of commonly used stimulants that can cause a person to be tweakin. They can become fast-moving, jittery and if on meth violently jumpy or shaky (trembling)

2) ADD/ADHD, natural high, sugar high, caffeine high can cause tweakin (hypetactivity) where you'll just be all over t he place moving fast.

when someone is hyperactive it doesnt mean they are under the influence of methamphetamine where meth high causes similar behaviour but is a different kind of hyper.
by skaterjack October 06, 2006
smoking meth
Dude he was tweakin' really bad
by rollin_balls February 24, 2009
Acting senseless or saying random things for no apparent reason or either under the influence of marijuana.
"Man, Janet is high and she tweakin' hard."
by THA.ONE April 30, 2009

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