(v) To be high on amphetamine.
"We be tweakin, like every single weekend, we be tweekin."

"Last night I danced for 10 hours, I was tweakin hard."
by saeed October 20, 2003
Top Definition
1.To be high on stimulants like Meth or coke.
2.To work obsessively or compulsively on something.
3.To adjust something.
4.To be way wrong about something
1.He did 4 fat ass lines, hes tweakin hard
2.I was tweakin on my room for like 4 hours
3.I was just Tweakin the carb on my truck
4.you think the Boston Celtics are the best team ever..man your tweakin.
by Steve_Juggernaut April 28, 2006
Outside of your normal boundaries
Boy 1: "Which came first the chicken or the egg?"
Boy 2: "Boi, what the.."
Boy 1: "My fault I'm tweakin"
by Giddy April 24, 2005
1) to be high on stimulant supplements(vitamins) or drugs.

2) to be hyperactive.
1) sugar, caffeine, monster drinks, sugar, earl gray tea, amphetamine, methamphetamine are examples of commonly used stimulants that can cause a person to be tweakin. They can become fast-moving, jittery and if on meth violently jumpy or shaky (trembling)

2) ADD/ADHD, natural high, sugar high, caffeine high can cause tweakin (hypetactivity) where you'll just be all over t he place moving fast.

when someone is hyperactive it doesnt mean they are under the influence of methamphetamine where meth high causes similar behaviour but is a different kind of hyper.
by skaterjack October 06, 2006
Acting senseless or saying random things for no apparent reason or either under the influence of marijuana.
"Man, Janet is high and she tweakin' hard."
by THA.ONE April 30, 2009
when you buck on somebody or think somebody thinks youre always thinking about them.
that bitch was tweakin' on the haunting of conneticut she thank somebody always tryna haunt her ass.
by pinkmonkey August 29, 2009
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