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15.
a legitmate word meaning to pluck, or pull, and other non slang variations, but the slang variant was originally used to indicate the stage of a drug induced high, usually immediately following dosing, that indicates the climax of the high and the shift from sobriety into being extreme intoxication. Users were left alone when they "tweak," or are "tweaking out" until the initial strong effects of the drug wore off a little and they were more coherent.

The term has come to loosely refer to being high on speed, as well as unfortunately children who have been exposed to meth amphetamines in utero, parodied on shows including South Park.
You might act a little crazy when you tweak, but you'll come down in a minute or two.
by Lady Artemis April 02, 2010
 
1.
to be under the influence of methamphetamine.
"man i got all tweaked two days ago and i'm still awake"
by x September 02, 2003
 
2.
(n.) methamphetamine
(v.) the act of consuming methamphetamines
'Where might I find some tweak'
'He was totally tweaking'
by Kathy McGinty February 17, 2003
 
3.
The Evolution of Tweak and it's Various Verbal Meanings:
1. Tweak- to touch something up, fiddle with the finishing touches or make tiny little changes.
2. Tweak- To perfect in an Obsessive Compulsive Disorder-ish way
3. Tweak- Little over-caffinated kid with various bizarre nervous-tics who lives in South Park
4. To be on some type of speed and be any/all of the following: --Highly aggitated, wide eyed, and angry/overly irritable --To be as paranoid in a mouselike manner; rapid breathing, weird twitchy and/or panic-ey movements/responses --To be euphoric as a motherfucker whilst on some type of upper( which is usually taken in a rather large amount to induce such energized and super-human like euphoric oddness)
--Just really fucking cracked out, in any way, as long as its super conspicuously performed behavior that is commonly associated with crackheads/random speed-heads --To be using or experiencing some feeling or difference caused by the use of Methamphetamines
1. " I just gotta tweak a little bit here and there and it will be perfect."
2. "I just gotta tweak this and THIS AND THIS AND THIS and this and OHH NO now this..."
3.How do I make an example of this? If you don't watch the fucking show, what does the example matter to your familiarity?
4. "Dude your fucking twitching and grinding your teeth like a goddamned crackhead, wouldya quit pacin' around freaking about shit all quarter-eyed like that?"
::shaking, wide-eyed in the corner, head tucked behind huddled knees:: "Icantcomeout--gassp. Thh-thhuah--THEYLL GET ME!"::
"OH-MY-GOD- YOUGUYSWATCHICANRUN - AND! - READTHISBOOK -ATTHESAMETIME! WITHOUT RUNNINGINTOSTUFFHOLYCRAP! I'm god." ::scampers about rapidly, limbs a-flurry and a manic smile plastered to their face::
"Dude, seriously, it's probably just because you're a meth-head"
 
4.
To improve. To modify so it runs better, faster, and more efficiently.
Linux programmers seriously need to learn how to tweak their operating system so it doesn't eat up so much RAM.
by former penguin February 17, 2003
 
5.
To be Up and Fidgity From doing Crystal Meth.
When It's 4 AM U havent slept for days and Ur still wide away your TWEAKING
by Lisa April 09, 2004
 
6.
to make a fine adjustment
he tweaked the radio dials, hoping to peak the signal into intelligibility
by Jake February 25, 2004
 
7.
1) to be stimulated by consuming high amounts of caffeine or sugar.
2) to use amphetamine or methamphetamine.
i drank 3 monster drinks and ate a few candy bars at the skatepark and i was seriously tweakin'

a grip of anphetamine pills or a couple of lines of meth can cause you to tweaki all night.
by skaterjack October 05, 2006