Vash, the Main character is a goofy protagonist, just trying to figure out who he is, and trying to get by. He is also being followed by Meryll Stryfe and Milly Thompson, two insurance girls from the Bernadelli Insurance firm, and they are trying to make sure that more Vash the Stampede incidents do not occur. However, the irony is that Vash does not put himself in danger, nor does he intend to cause such trouble, and he is an extremist pacifist, and refuses to kill ANYONE.
A truly interesting and heart-warming series, and is worth looking into, despite all of the fan boys.
What makes this show truly great is the philosophy behind it. There is philosophy behind (almost) all anime, but Trigun's is one-of-a-kind.